WebDec 16, 2024 · Perineuronal nets (PNNs) are a complex of ECM molecules that mostly surround the soma and dendrites of GABAergic neurons in various brain regions, including the forebrain, midbrain, and cerebellum … WebPerineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular matrix structures with heterogeneous composition yet specific organization. They typically assemble around a subset of fast-spiking interneurons that are implicated in learning and memory. Owing to their unique structural organization, PNNs have ...
Activation of perineuronal net-expressing excitatory neurons …
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Removal of perineuronal nets disrupts recall of a remote fear …
WebAug 15, 2024 · PNNs are condensed extracellular matrix (ECM) structures that surround neurons, forming a key element of the tetrapartite synapse. PNNs have multiple roles, but two of the most critical are the regulation of plasticity by stabilising synapses, and the protection of neurons and synaptic connections against damaging environmental … WebNov 9, 2016 · PNNs were first described as reticular structures by Golgi in the late 1800s (Spreafico et al., 1999), but only recently has there been intense focus on the role of … WebApr 5, 2024 · Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are thought to be expressed around inhibitory neurons and contribute to critical periods … how to remove shower curtain stains