WebApr 6, 2024 · The quasi-steady-state (QSS) approximation assumes that the binding rate of drug and target is balanced by the sum of the dissociation and internalization rate (k int) of drug-target complex (RC) (i.e., k on × C free × R = (k off + k int) × RC, with the steady-state constant being defined as K ss = (k off + k int)/k on) [20, 21] . WebThe study compared maximum drug concentration (C(max)) and area under the time-concentration curve (AUC) after normalization of doses to body weight and to body …
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WebThe systemic drug absorption from the gastrointestinal (GI) tract or from any other extravascular site is dependent on (1) the physicochemical properties of the drug, (2) the type and design of dosage form, and (3) … WebCmax (Peak Plasma Concentration) - Maximum concentration of drug in plasma. Tmax (Time of peak plasma conc.) -Time taken by the drug to reach Cmax (Unit-hrs). T1/2 (Elimination half life/ Plasma ... WebDrug absorption data are critical in bioequivalence comparisons, and factors such as the maximum drug concentration (C max), time to achieve C max (or T max), as well as the … help profee.com