Clec9a ligand
WebCLEC9a: Products C-type lectin-like domain-containing family members constitute a large and diverse group of extracellular proteins. With the exception of CLEC1A (CLEC1) and … WebIt recognizes a ubiquitous preformed acid-labile protein associated ligand (s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk. Product Details Technical data sheet Product Details Isotype Control
Clec9a ligand
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WebCD370 (CLEC9A), also known as DNGR1, is a type II transmembrane protein consisting of a single extracellular C-type lectin domain (CTLD) that is connected to the … WebWe have identified this Clec9A ligand as a filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins. We have determined the crystal structure of the human CLEC9A C-type lectin domain and propose a functional dimeric structure with conserved tryptophans in the ligand recognition site. Mutation of ...
WebMontgomery County, Kansas. Date Established: February 26, 1867. Date Organized: Location: County Seat: Independence. Origin of Name: In honor of Gen. Richard … WebApr 5, 2012 · Clec9A recognizes a conserved component within nucleated and nonnucleated cells, exposed when cell membranes are damaged. We have identified this Clec9A ligand as a filamentous form of actin in …
WebJun 12, 2024 · The CLEC9A-WT1 vaccine is a promising candidate immunotherapy for malignancies that express WT1. Introduction Relapse after initial treatment is a major problem in the clinical management of … WebNov 11, 2011 · Detection of CLEC9A ligand and CLEC9A expression. To detect the expression of the CLEC9A ligand, a recombinant soluble FcmILZ-CTLD9A receptor that contains a c-type lectin dormain (CTLD) fused to C-terminal of human IgG and trimerization isoleucine zipper (ILZ) was made. The human Fc fragment of the soluble fusion receptor …
WebCLEC9A recognizes a ubiquitous preformed acid-labile protein associated ligand (s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk. Product Details Technical data sheet Product Details Isotype Control
WebCLEC9A Protein Overview: Sequence, Structure, Function and Protein Interaction CLEC9A Protein Overview CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions … butter sugar cookies recipe from scratchWebDNGR-1 (CLEC9A) is particularly interesting because of its restricted pattern of expression in DCs that may be exploited for cancer therapy. It has recently been revealed that DNGR-1 binds damaged or dead cells via … cedar grove sports calendarWebFeb 21, 2024 · Therefore, we designed bispecific antibodies that target CD40 activation preferentially to dendritic cells, by coupling the CD40 agonist arm with CD11c-, DEC-205- or CLEC9A-targeting arms. These... cedar grove stables bothell waWebMar 17, 2016 · The crystal structure of CLEC9A was reported in the apo form (PDB ID: 3VPP) (Zhang et al. 2012). The putative ligand recognition site of CLEC9A is similar to those of other CLRs. Two mutations located at this face, W131A and W227A, disrupt the ability to bind F-actin, supporting the idea that this face is a ligand recognition site. butter sugar creamWebThe natural ligand for CLEC9A is the intracellular cytoskeletal protein F-actin that becomes exposed on necrotic cells. In contrast to other C type lectins that signal through NF-κB and induce an inflammatory signature, CLEC9A signals through spleen tyrosine kinase (SYK) after F-actin binding. cedar groves high schoolWebFirst, the authors investigated the ligands for CLEC9A by establishing a reporter system composed of the extracellular domains of CLEC9A fused to CD3ζ and expressed by T … butter sugar cookies from scratchWebet al. (2010) also found Clec9A+ DCs The murine dendritic cell network comprises multiple subsets with distinct functions, but few of their human counterparts have been described. New data now reveals the likely human equivalent of the mouse DC subset special-ized in cross-presentation. cedar grove shreveport