WebThe HIF3α gene undergoes complex regulation and produces a large number of long and short mRNA splice variants, which are translated into different polypeptides. These … Web一些研究表明在各种癌症中 Nrf2 信号通路组成性激活会促进癌细胞的生长和增殖,阻止细胞凋亡,增强癌症干细胞 (CSC) 的自我更新能力,更重要的是,可增强癌细胞的化学耐药性和放射抗性。. 因此,阻断 Nrf2 信号是一种有前途的癌症治疗方法,特别是对于 Nrf2 ...
Zebrafish Hif3α modulates erythropoiesis via regulation of
Web21 de mar. de 2024 · HIF3A (Hypoxia Inducible Factor 3 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF3A include Erythrocytosis, Familial, 4 and … Web1 de jul. de 2024 · Background: Methylation of the hypoxia-inducible factor 3α gene (HIF3A) has been linked to pregnancy exposures, infant adiposity and later BMI. Genetic … stuart and stuart
HIF3A hypoxia inducible factor 3 subunit alpha [ (human)]
WebHIF3A Gene. HIF3A. The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. Web30 de out. de 2024 · Summary. The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. Weberages for the two HIF3A regions investigated in this study (herein referred to as HIF3A.1 and HIF3A.2) are shown in Fig. 1. The mean average methylation level across HIF3A.1 was 70.3% (SD 4.5), with mean methylation of individual CpG units ranging from 59.5 to 80.8%. HIF3A.2 was gen-erally less methylated, with a mean average methylation stuart and stewart difference