site stats

Plectin网蛋白

Webb19 sep. 2024 · Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies.The most common disorder is autosomal recessive disease epidermolysis bullosa simplex with muscular dystrophy … WebbAn in situ proximity ligation assay confirmed that FUS-plectin interactions take place in the cytoplasm of cells. Furthermore, plectin deficient cells showed an altered subcellular localization of FUS and a deregulated expression of mRNAs bound to FUS. Our results show that plectin is important for normal FUS localization and function.

Plectin mutation analysis and expression across several cancers.

Webb14 okt. 2008 · Description. A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma. EBS5C is an autosomal recessive disorder characterized by severe skin blistering at birth and congenital pyloric atresia. Death … Webb30 apr. 1996 · Plectin, a 500-kDa intermediate filament binding protein, has been proposed to provide mechanical strength to cells and tissues by acting as a cross-linking element … headboard how to https://tommyvadell.com

网蛋白 - chinese_english.en-academic.com

Webb15 sep. 2013 · Plectin is a versatile cytolinker of the plakin family conferring cell resilience to mechanical stress in stratified epithelia and muscles. It acts as a critical organizer of the cytoskeletal system by tethering various intermediate filament (IF) networks through its C-terminal IF-binding domain (IF … WebbPlectin Plectin, also referred to as IFAP 300 or HD1, is a 500-kDa plakin family member. It is particularly important for hemidesmosome function in epithelial tissues, and as a … Webb12 nov. 2024 · 经蛋白组学分析，靶向肽PTP是通过与胰腺癌发生时误定位在细胞膜表面上的plectin-1特异性结合实现靶向作用的。 然而，胰腺癌在遗传上是非常复杂的，肿瘤的质量是由患者的63个基因改变和12个核心信号通路的异常引起的，在不同癌症患者的肿瘤生物标志物表达中存在异质性。 head board image code

PLEC Gene - Altmeyers Encyclopedia - Department Dermatology

Category:Targeted inactivation of plectin reveals essential function in ...

Tags:Plectin网蛋白

Plectin网蛋白

Cells Free Full-Text Muscle-Related Plectinopathies

Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these different networks together, plectin pl… Webb网蛋白（plectin）是半桥粒组成成分中分子量最大的一种，约500kD，和BPAG1同处于半桥粒的细胞内侧，位于半桥粒内斑块的细胞最内缘，比BPAG1位置略高。 网蛋白对多种蛋 …

Plectin网蛋白

Did you know?

Webb4 apr. 2024 · plectin, hemidesmosomal protein 1, plectin 1, intermediate filament binding protein 500kDa GeneRIFs: Gene References Into Functions Plectin Downregulation …

Webb15 apr. 2008 · As an in vivo screening approach, we have used phage as targeted nanoparticles for imaging by labeling the phage coat proteins with a near infrared fluorochrome [ 21, 27 ]. The Cy5.5-labeled phage were injected IV 4 h prior to imaging for both the distribution and tumor imaging studies. Webb除原位胰腺组织外，Plectin-1在转移性病变包括肝脏、淋巴结和腹膜组织的免疫组化研究中均有显着表达。通过上述研究说明，Plectin-1的表达特点和表达量可用于鉴别胰腺的良恶性病变，可成为特殊的生物标记。

Webb1 sep. 1998 · Plectin and its isoforms are versatile cytoskeletal linker proteins of very large size (>500 kDa) that are abundantly expressed in a wide variety of mammalian tissues and cell types. Earlier studies indicated that plectin molecules were associated with and/or directly bound to subcomponents of all three major cytoskeletal filament networks, the … WebbThe cytolinker protein plectin anchors IF networks to junctional complexes, the nuclear envelope and cytoplasmic organelles and it mediates their cross talk with the actin and tubulin cytoskel-eton. These functions empower plectin to wield significant influence over IF network cytoarchitecture. Moreover, the unusual diversity of plectin isoforms

Webb3 aug. 2012 · Plectin, a giant multifunctional cytolinker protein, plays a crucial role in stabilizing and orchestrating intermediate filament networks in cells. Mutations in the human plectin gene result in multiple diseases manifesting with muscular dystrophy, skin blistering, and signs of neuropathy. The most common disease caused by plectin …

WebbPlectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies. The most common disorder is autosomal recessive disease epidermolysis bullosa simplex with muscular dystrophy (EBS-MD), which is … goldhipsWebb30 aug. 2024 · Background Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proliferation, migration, adhesion, and metastasis in melanoma. Plectin, a cytoskeletal … goldhips.comWebb21 mars 2024 · PLEC (Plectin) is a Protein Coding gene. Diseases associated with PLEC include Epidermolysis Bullosa Simplex 5A, Ogna Type and Muscular Dystrophy, Limb … headboard ikea hack shelvesWebb30 juni 2024 · 存储条件-20℃以下冰冻、干燥、避光。长期保存惰性（氩气或者氮气）保护。产品化学性质PTP-PEG-DSPE磷脂-聚乙二醇-胰腺癌靶向肽PTP与胰腺癌发生时误定位在细胞膜表面上的plectin-1特异性结合实现靶向作用。本产品仅用于研究和制造用途，不能用于人类或诊断用途。 gold hippo bowlWebb4 jan. 2024 · Definition. Plectin gehört zur Proteinfamilie der Plakine. Plectin kommt bei Eukaryoten vor, so auch beim Menschen. Plectin ist ein 500 kDa großes an intermediäre Filamente bindendes Strukturprotein, das im Zytoplasma nahezu aller Zellen nachweisbar ist, so v.a. in Muskel- und Herzmuskelzellen, in Epidermiszellen, Nervenzellen sowie in ... headboard ideas wood wallWebb凝集素是重要的结构和部分功能相关蛋白家族的重要成员，这些蛋白称为plakins或细胞连接剂，能够相互连接细胞骨架的不同元素。. Plakins具有多域结构和巨大的尺寸，不仅在 … headboard in a boxWebb16 maj 2024 · 2024年5月16日讯/生物谷BIOON/---选择性剪接（alternative splicing）是一种转录后调控机制，对转录组和蛋白质组的多样性至关重要。 通过增加蛋白水平的复杂性，选择性剪接可以引起细胞的功能变化。 众所周知，RNA结构元件在转录后调控过程（包括选择性剪接）中起着关键作用。 因此，由RNA二级结构编码的调节信息对选择性剪接决定的 … gold hip hop necklace